HIV/AIDS Topics Experimental Vaccine Offers Partial Protection against HIV-Related Virus in Monkeys
- Details
- Category: HIV Vaccines
- Published on Saturday, 10 December 2011 00:00
- Written by NIAID
An investigational adenovirus prime-poxvirus booster vaccine regimen reduced the likelihood of infection in rhesus monkeys exposed to simian immunodeficiency virus (SIV), a monkey virus similar to HIV, researchers reported in the January 4, 2011, advance online edition of Nature. The vaccine reduced infection risk by about 80% compared with placebo, and monkeys that did become infected had lower viral loads.
Truvada Drug Levels in Vaginal and Rectal Tissue Offer Clues to HIV PrEP Puzzle
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- Category: HIV Prevention
- Published on Friday, 09 December 2011 00:00
- Written by Liz Highleyman
The 2 drugs in the Truvada pill -- tenofovir and emtricitabine -- reach different concentrations in human cervical, vaginal, and rectal mucosa tissues and fluids, according to new research published in the December 7, 2011, issue of Science Translational Medicine. Lower drug levels in the female genital tract suggest that women may need higher doses to achieve a prophylactic effect, which may help explain conflicting results from some recent biomedical HIV prevention trials. 
U.S. Conference on AIDS Focuses on Treatment as Prevention, Impact of Stigma
- Details
- Category: Treatment as Prevention
- Published on Tuesday, 15 November 2011 00:00
- Written by Liz Highleyman
Nearly 3000 participants gathered this week in Chicago for the 15th U.S. Conference on AIDS (USCA), an annual meeting sponsored by the National Minority AIDS Council (NMAC) focused on the domestic HIV/AIDS epidemic.
VOICE HIV Prevention Trial Halts Tenofovir Gel Arm
- Details
- Category: HIV Prevention
- Published on Tuesday, 29 November 2011 00:00
- Written by Liz Highleyman
On November 25 the National Institutes of Health (NIH) and the Microbicide Trials Network (MTN) announced the discontinuation of an arm of the VOICE study that was evaluating a tenofovir vaginal microbicide, due to lack of effectiveness in an interim analysis.
UC781 Rectal Microbicide Appears Safe and Well-Tolerated
- Details
- Category: HIV Prevention
- Published on Tuesday, 15 November 2011 00:00
- Written by Press Release
The investigational rectal microbicide gel UC781 produced no adverse events and study participants said they would be likely to use it if found effective at reducing the risk of HIV infection, according to a study described in the September 28, 2011, edition of PLoS Medicine.
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